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. 2020 Jun;31:100391. doi: 10.1016/j.epidem.2020.100391

Table 1.

Variables, distributions, parameters, and settings used in the simulation study of different scenarios.

Variables Distributions &parameters References
Ward 58 &59, Kolkata
 · Population Npop 160,000 Kolkata Municipal Corporation Website (2018)
 · Number of households Nhh 30,000 Unpublished Data
 · Number of shared toilets Ntol 3000 Estimated
 · Water use per capita Vuse 200 L/day Basu (2015)
 · Water loss Ql 35% Basu (2015)
Simulated sewerage network
 · Number of pumping station Npump 1
 · Number of edges Nedge 1000
 · Number of nodes (toilets) Nnode 3000
Shedding dynamics
 · Infection pressure λ
 · Time (day) t
 · Seasonality multiplier ms ms=sin(2πt/365)+12
 · Number of new infections Xt Poisson(msλ) generated on day t
 · Number of new infections generated on day t and entering at toilet i Xt,i, i=1,2,,n
 · Number of days infections duration Tshed 14 days Gibani et al. (2019)
 · Probability of shedding given the day of infection (tinf) P(shedding|tinf) NB(r=3,p=0.4) Gibani et al. (2019), Assumption
P(shedding|tinf)=5·r+tinf+1tinfpinft(1p)r
 · Number of S. Typhi shed (N) for the day given shedding P(N|shedding) Lognormal(μ=17.92,σ=1) Expert Communication, Assumption
P(N=x|shedding)=1σx2πe(log(x)μ)2/2σ2
 · Number of S. Typhi entering toilet i on day t Nt,i, i=1,2,,n
 · Percent of decay and loss of S. Typhi P(Qd|d) P(Qd=x|d)=1Γ(k)θkxk1ex/θ Assumption
 (Qd) given the distance d slow: k=1,θ=0.25
rapid: k=1,θ=2
Sampling
 · Volume of samples Vs PS: 40 L Pilot Study
shared toilet: 0.5 L
PSU: 0.5 L
 · Number of toilets pooled per PSU npool 5
 · Number of sampling sites ns PS: 1
shared toilet: 9
PSU: 9
 · LLOD of lab detection Cdet low sensitivity Pilot Study
PS: 25 GEC/L
shared toilet or PSU: 2000 GEC/L
high sensitivity
PS: 0.25 GEC/L
shared toilet or PSU: 20 GEC/L
Adaptive sampling site allocation
 · Number of days per sample ndays/sample 7
 · Number of samples per update nsamp/update 12
 · Number of sites relocated per update nreloc/update 2