Table 4.
Compound | Concentration (μM) | Pretreatment | Cotreatment | Posttreatment | |||
---|---|---|---|---|---|---|---|
48 h | 72 h | 48 h | 72 h | 48 h | 72 h | ||
Curcumin | 2.5 | 0.00 ± 0.00a | 0.58 ± 1.00a | 12.34 ± 2.23a | 5.76 ± 4.13a | 0.85 ± 1.35a | 0.05 ± 0.08a |
5 | 0.38 ± 0.66a | 1.74 ± 1.06ab | 21.98 ± 7.01b | 11.99 ± 3.43b | 0.08 ± 0.13a | 0.99 ± 1.71a | |
10 | 3.87 ± 1.64ab | 1.16 ± 1.82a | 40.08 ± 3.71d | 18.82 ± 1.93c | 13.31 ± 3.93b | 2.59 ± 1.55a | |
20 | 12.79 ± 2.27c | 5.12 ± 2.03bc | 55.95 ± 1.82e | 22.25 ± 2.05c | 17.28 ± 0.78bc | 2.13 ± 1.91a | |
Cur-CS nanoparticles | 2.5 | 0.98 ± 1.70a | 0.89 ± 1.30a | 11.52 ± 2.93a | 6.29 ± 4.28a | 0.34 ± 0.59a | 0.42 ± 0.73a |
5 | 6.53 ± 4.46b | 1.30 ± 2.26ab | 32.51 ± 3.53c | 12.23 ± 3.03b | 3.87 ± 3.34a | 1.12 ± 1.01a | |
10 | 14.43 ± 6.27c | 7.98 ± 3.93c | 49.37 ± 2.95e | 21.18 ± 1.91c | 18.02 ± 2.21c | 3.06 ± 1.00a | |
20 | 20.12 ± 3.71d | 11.67 ± 1.76d | 67.88 ± 4.08f | 28.43 ± 3.92d | 31.25 ± 3.19d | 12.24 ± 4.46b |
Data are presented as mean ± SD (n = 3) and analysed using one-way ANOVA and post hoc Duncan multiple test. For each time interval, means within a column with different roman letters were significantly different (p < 0.05) from each other. Cur-CS: curcumin-encapsulated chitosan.