Table 9.
Pharmacokinetic parameters of curcumin and Cur-CS nanoparticles given s.i.d. and b.i.d. orally in healthy cats.
| Formulation | Curcumin | Cur-CS nanoparticles |
|---|---|---|
| Single dosing (s.i.d.) | ||
| C max (ng/mL) | 219.6 ± 18.6 | 485.0 ± 36.2∗ |
| T max (h) | 3 | 4 |
| AUC0-12 (ng/mL h) | 1139.3 ± 136.7 | 3015.6 ± 385.7∗ |
| AUC0-∞ (ng/mL h) | 1374.5 ± 112.1 | 3476.0 ± 505.3∗ |
| Two dosing (b.i.d.) | ||
| C max (ng/mL) | 241.1 ± 27.1 | 621.5 ± 38.2∗ |
| T max (h) | 4 | 4 |
| AUC0-12 (ng/mL h) | 1508.0 ± 72.4 | 3733.1 ± 132.9∗ |
| AUC0-24 (ng/mL h) | 3098.9 ± 176.2 | 9316.9 ± 169.0∗ |
Data are presented as mean ± SD (n = 4) and analysed using paired sample t-test. For each parameter, means with an asterisk (∗) were significantly (p < 0.05) different from the control (curcumin). Cur-CS: curcumin-encapsulated chitosan.