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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Cell Rep. 2019 Dec 17;29(12):4200–4211.e7. doi: 10.1016/j.celrep.2019.11.065

Figure 2. Intra-TAD Promoter-Centric Interactions Exhibit Large Dynamics.

Figure 2.

(A) Venn diagram of TADs with dynamic intra-TAD interactions during fetal-to-adult HSC transition.

(B) Enriched GO terms among genes in the TADs with dynamic intra-TAD interactions.

(C) An example TAD with more promoter-centric interactions in FL HSCs than BM HSCs. Gene promoters with Capture-C baits are highlighted in red. TAD is indicated with a navy green bar. The normalized signals of ATAC-Seq, H3K4me1, H3K27ac, and Capture-C are displayed for FL HSCs (upper tracks) and BM HSCs (lower tracks). Two super enhancers are indicated with an orange bar.

(D) An example TAD with more promoter-centric interactions in BM HSCs than FL HSCs (indicated by arrows).

(E) Expression levels of three genes, Hmga2, Llph, and Smarca2 in the TAD. p value for differential expression was computed using the edgeR software.