Table 1.
Published cases of carcinoma arising from heterotopic pancreas in the stomach
| Ref. | Sex, age (yrs) | Location | Appearance | Clinical symptoms | Heinrich type | Outcome (time after treatment) | Size in cm | Tumor markers |
| Goldfarb et al[15], 1962 | F, 55 | Pylorus | Stenotic with ulceration | Abdominal pain, weight loss, vomiting | I | Recurrence (6 yr) | 6.0 | NR |
| Tanimura et al[16], 1979 | F, 55 | Antrum | Submucosal tumor | GI bleeding, gastric discomfort, lumbago, pain in the right leg | II | Death (1 mo) | 0.5× 2 × 2 | NR |
| Ura et al[17], 1997 | F, 60 | Lesser curvature | Extramural mass | Asymptomatic | I | NR | 1.8 × 1.3 | CEA and CA199 were normal |
| Osanai et al[14], 2001 | F, 57 | Lesser curvature | Protruding lesion with a central ulcer | Epigastric discomfort and periodic nausea | II | Death (13 mo) | 12.5 × 9 | NR |
| Halkic et al[18], 2001 | M, 60 | Esophagogastric junction | Stenotic, ulcerated | Epigastric pain, dysphagia, weight loss | I | Death (4 mo) | 6×4.5×4 | NR |
| Jeong et al[19], 2002 | M, 64 | Antrum | Subepithelial tumor, stenotic | Dyspepsia, vomiting | I | Uneventful (1 yr) | 3×3 × 1.5 | NR |
| Song et al[4], 2004 | M, 35 | Antrum | Submucosal tumor | Asymptomatic | III | Uneventful (5 mo) | 2×1.7×1.2 | CEA, CA199 and CA724 were normal |
| Chetty et al[20], 2004 | M, 85 | Antrum | Ulcer | Dyspepsia, increase in stool frequency | I | Uneventful (1 mo) | 1.7×1.7×0.9 | NR |
| Emerson et al[21], 2004 | M, 52 | NR | Stenotic | Epigastric, left upper quadrant pain, emesis, and bloating | III | Uneventful (9 mo) | 4.0×2.5×1.5 | NR |
| Matsuki et al[13], 2005 | F, 58 | Prepyloric region | Gastric outlet obstruction | Vomiting | II | Metastasis (1.5 yr) | NR | CEA and CA199 were normal |
| Kimura et al[22], 2008 | F, 31 | Pyloric ring | Submucosal tumor | Epigastralgia | II | NR | 5.0×2 | CA199: 660 U/mL; CA125: 40.8 U/mL |
| Papaziogas et al[23], 2008 | F, 56 | Antrum | Ulcerated lesion | Epigastric pain, nausea and vomiting | III | Uneventful (6 mo) | 2× 1.2 | CEA, AFP, CA199, CA-125 and CA-724 were normal |
| Okamoto et al[24], 2012 | F, 74 | Middle corpus | Submucosal tumor | Epigastralgia | I | Uneventful (11 yr) | 2.0 × 2.0 × 2.0 | CEA: 8.7 ng/mL, CA199: 287.4 U/mL |
| Lemaire et al[25], 2014 | M, 60 | Lesser curvature | NR | Dyspepsia and epigastric heaviness | NR | Disease-free (4 yr) | 7.5×4.4 | CA199: 40 U/mL |
| Endo et al[26], 2014 | M, 73 | Antrum | Submucosal tumor | Epigastric pain and abdominal fullness | I | Metastasis (2 yr) | 3.2×2.4 | CEA and CA199 were normal |
| Priyathersini et al[27], 2017 | M, 45 | Antrum | Submucosal mass | Early satiety, vomiting, and constipation | II | Uneventful (12 mo) | 5×4.3×3.5 | NR |
| Present case | F, 44 | Antrum | Submucosal tumor, stenotic | Abdominal distension, vomiting | III | Disease-free (9 mo) | 3×4 | CA724: 50.1 kU/L, CEA and CA199 were normal |
AFP: Alpha-fetoprotein; CA199: Carbohydrate antigen 19-9; CA724: Carbohydrate antigen 72-4; CEA: Carcinoembryonic antigen; F: Female; GI: Gastrointestinal; M: Male; NR: Not reported.