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. 2020 Apr 28;2(1):vdaa053. doi: 10.1093/noajnl/vdaa053

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© The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Influence of IDH and BRAF mutations on GPR133 expression. (Ai) GPR133 expression, as assessed by immunohistochemistry, is higher in the core of IDH wild-type gliomas compared to IDH mutant and BRAF mutant gliomas (P < .0001, Kruskal–Wallis test; post hoc Dunn’s *P < .05; **P < .01; ****P < .0001). (Aii) Similar comparisons in the infiltrative edge of such tumors (P = <.0001, Kruskal–Wallis test; post hoc Dunn’s ***P < .0005). (Bi) There is no difference in GPR133 expression within the core of 1p19q codeleted versus non-codeleted IDH mutant gliomas (Mann–Whitney test; ns, P > .05). (Bii) The infiltrative edge of non-codeleted IDH mutant gliomas shows higher levels of GPR133 expression (Mann–Whitney test; *P < .05). (Ci) GPR133 expression is equivalent within the core of IDH mutant gliomas with preserved or lost ATRX (Mann–Whitney test; ns, P > .05). (Cii) The infiltrative edge of ATRX loss IDH mutant gliomas shows higher levels of GPR133 expression (Mann–Whitney test; *P < .05).