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. Author manuscript; available in PMC: 2021 May 28.
Published in final edited form as: J Med Chem. 2020 May 12;63(10):5526–5567. doi: 10.1021/acs.jmedchem.0c00424

Table 7.

Affinities1 of 20 and pramipexole for inhibiting either [3H]-methylspiperone or [3H]-7OH-DPAT binding to the D3R in various buffer systems.

[3H]-Methylspiperone Ki (nM) [3H]-7-OH-DPAT Ki (nM)
EBSS Tris Tris + Na+ EBSS Tris Tris + Na+ Tris + Mg2+
20 3,700 ± 900 350 ± 130 1,500 ± 370 720 ± 31 22 ± 3.7 94 ± 11 12.5 ± 3.8
Pramipexole 8.2 ± 2.0 13 ± 0.8 17 ± 0.6 1.1 ± 0.3 0.94 ± 0.24 5.6 ± 1.3 ND
1

Ki (nM) values for the indicated compounds were determined as described in the Experimental Section.

Data are expressed as mean ± S.E.M. of individual experiments performed 3–16 times.

ND indicates that the value was not determined.