Table 1.
Patient and Transplant Characteristics
| Patient characteristics | N (%) |
|---|---|
| Number of patients | 5022 |
| Number of centers | 183 |
| Age, median (range), years | 8 (<1-21) |
| Age group (years, y) | |
| <1 | 623 (12) |
| 1-<2 | 382 (8) |
| 2-<5 | 816 (16) |
| 5-<10 | 1183 (24) |
| 10-<21 | 2018 (40) |
| Indication for transplant | |
| Malignancies | |
| AML/MDS | 1248 (25) |
| ALL | 949 (19) |
| Other leukemia | 128 (3) |
| Lymphomas | 117 (2) |
| Other malignancies | 10 (<1) |
| Non-malignant diseases | |
| Aplastic Anemia | 449 (9) |
| Erythrocyte disorders | 869 (17) |
| SCID & other immune deficiencies | 752 (15) |
| Metabolic diseases | 295 (6) |
| Histiocytic disorders | 171 (3) |
| Other non-malignantα | 34 (<1) |
| Conditioning intensity | |
| MAC | 3552 (71) |
| RIC | 579 (11) |
| NMA | 566 (11) |
| No conditioning (non-malignant only) | 209 (4) |
| Missing | 118 (2) |
| TBI used in conditioning | |
| Yes | 1662 (33) |
| No | 3246 (65) |
| Missing | 114 (2) |
| Donor type | |
| HLA-identical sibling | 973 (19) |
| Other related | 662 (13) |
| Well-matched unrelated | 860 (17) |
| Partially-matched unrelated (partial and mis-matched) | 353 (7) |
| Unrelated match unknown | 83 (2) |
| Cord blood | 2089 (42) |
| Missing | 2 (<1) |
| Graft type | |
| Bone marrow | 2070 (41) |
| Peripheral blood | 863 (17) |
| Umbilical cord blood | 2089 (42) |
| Donor/recipient CMV serostatus | |
| +/+ | 1171 (23) |
| +/− | 384 (8) |
| −/+ | 655 (13) |
| −/− | 614 (12) |
| CB - recipient + | 1128 (22) |
| CB - recipient − | 909 (18) |
| CB - recipient CMV unknown | 52 (1) |
| Missing | 109 (2) |
| Pulmonary comorbidity | |
| No pulmonary disease | 4436 (88) |
| Moderate pulmonary disease | 308 (6) |
| Patient characteristics | N (%) |
| Severe pulmonary disease | 217 (4) |
| Missing | 61 (1) |
| Median follow-up of survivors (range), months | 31 (1-96) |
α
Other non-malignant: Platelet disorder: n=24, autoimmune disorder: n=10