Table 3a.

Pulmonary toxicity incidences

	N eval	Prob (95% CI)		N eval	Prob (95% CI)		p-value
Disease type	Malignant (N = 2452)			Non-malignant (N = 2570)
Pneumonitis	2375			2508			<0.001
100-day			6 (5-7)%			5 (4-5)%
6 months			8 (7-9)%			5 (5-6)%
1-year			9 (8-10)%			6 (5-7)%
Diffuse alveolar hemorrhage	2377			2509			0.39
100-day			2 (1-2)%			2 (1-2)%
6 months			2 (2-3)%			2 (1-2)%
1-year			3 (2-3)%			2 (2-3)%
Pulmonary GVHD	2394			2541			<0.001
100-day			1 (0-1)%			0 (0-0)%
6 months			2 (2-3)%			1 (0-1)%
1-year			3 (3-4)%			1 (1-2)%
Conditioning intensity	MAC (N = 3554)			RIC/NMA (N = 1143)
Pneumonitis	3533			1136			<0.001
100-day			6 (5-7)%			3 (2-5)%
6 months			7 (7-8)%			4 (3-5)%
1-year			9 (8-10)%			5 (3-6)%
Diffuse alveolar hemorrhage	3535			1137			0.14
100-day			2 (2-3)%			1 (1-2)%
6 months			2 (2-3)%			1 (1-2)%
1-year			3 (2-3)%			2 (1-3)%
Pulmonary GVHD	3493			1123			0.002
100-day			1 (0-1)%			0 (0-1)%
6 months			2 (1-2)%			1 (0-1)%
1-year			3 (2-3)%			1 (1-2)%
Graft source	BM/PBSC graft (N = 2933)			Cord blood graft (N = 2089)
Pneumonitis	2885			1998			<0.001
100-day			4 (3-5)%			7 (6-8)%
6 months			5 (4-6)%			9 (7-10)%
1-year			6 (5-7)%			10 (9-11)%
Diffuse alveolar hemorrhage	2887			1999			<0.001
100-day			1 (1-1)%			3 (2-4)%
6 months			1 (1-2)%			3 (3-4)%
1-year			1 (1-2)%			4 (3-5)%
Pulmonary GVHD	2869			2063			0.48
100-day			0 (0-0)%			1 (0-1)%
6 months			1 (1-2)%			2 (1-2)%
1-year			2 (2-3)%			2 (2-3)%
Age, years	<1 (N = 623)		1 - <10 (N = 2381)		10 - <21 (N = 2018)
Pneumonitis	612		2307		1964		0.02
100-day		8 (6-10)%		4 (4-5)%		6 (5-7)%
6 months		8 (6-10)%		6 (5-7)%		7 (6-8)%
1-year		9 (7-12)%		7 (6-8)%		8 (7-9)%
Diffuse alveolar hemorrhage	613		2309		1964		<0.001
100-day		4 (3-6)%		1 (1-2)%		2 (1-2)%
6 months		4 (3-6)%		2 (1-2)%		2 (1-3)%
1-year		5 (3-7)%		2 (1-2)%		2 (2-3)%
Pulmonary GVHD	617		2358		1957		<0.001
100-day		0 (0-1)%		0 (0-1)%		1 (0-1)%
6 months		1 (0-1)%		1 (1-2)%		2 (1-2)%
1-year		1 (0-2)%		2 (1-2)%		3 (2-4)%