Table 3b.
Incidence of pulmonary toxicity
| Outcomes | N eval | Prob (95% CI) | N eval | Prob (95% CI) | N eval | Prob (95% CI) |
N eval | Prob (95% CI) |
N eval | Prob (95% CI) |
p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Less than 1 (N = 623) | 1 year (N = 382) | 2-4 years (N = 816) | 5-9 years (N = 1183) | 10-20 years (N = 2018) | |||||||
| Pneumonitis | 612 | 364 | 785 | 1158 | 1964 | ||||||
| 100-day | 8 (6-10)% | 6 (4-9)% | 4 (3-5)% | 4 (3-5)% | 6 (5-7)% | 0.04 | |||||
| 6 months | 8 (6-10)% | 7 (5-10)% | 6 (4-7)% | 5 (4-6)% | 7 (6-8)% | ||||||
| 1-year | 9 (7-12)% | 9 (6-12)% | 6 (5-8)% | 6 (5-8)% | 8 (7-9)% | ||||||
| Diffuse alveolar hemorrhage | 613 | 364 | 786 | 1159 | 1964 | ||||||
| 100-day | 4 (3-6)% | 2 (1-4)% | 1 (1-2)% | 1 (0-2)% | 2 (1-2)% | 0.001 | |||||
| 6 months | 4 (3-6)% | 2 (1-4)% | 2 (1-3)% | 1 (1-2)% | 2 (1-3)% | ||||||
| 1-year | 5 (3-7)% | 3 (1-5)% | 2 (1-3)% | 1 (1-2)% | 2 (2-3)% | ||||||
| Pulmonary GVHD | 617 | 379 | 808 | 1171 | 1957 | ||||||
| 100-day | 0 (0-1)% | 0 (0-1)% | 0 (0-0)% | 1 (0-1)% | 1 (0-1)% | <0.001 | |||||
| 6 months | 1 (0-1)% | 1 (0-3)% | 1 (0-1)% | 2 (1-3)% | 2 (1-2)% | ||||||
| 1-year | 1 (0-2)% | 2 (1-4)% | 1 (0-2)% | 2 (2-3)% | 3 (2-4)% | ||||||
DAH, diffuse alveolar hemorrhage; GVHD, graft-versus-host disease.