True positive |
Positive surveillance examination followed by diagnosis of ductal carcinoma in situ (DCIS) or invasive breast cancer within a follow-up period |
A radiologist finding requires additional work-up; woman diagnosed with a second breast cancer during follow-up |
False-positive |
Positive surveillance examination with no breast cancer diagnosed by end of follow-up |
A radiologist finding requires additional work-up; woman not diagnosed with a second breast cancer during follow-up |
False negative |
Negative surveillance examination followed by a diagnosis of DCIS or invasive breast cancer by the end of a follow-up period |
No radiologist findings require additional work-up, but woman diagnosed with a second breast cancer event during follow-up |
True negative |
A negative surveillance examination with no diagnosis of breast cancer by the end of a follow-up period |
No radiologist findings require additional work-up; woman is not diagnosed with a second breast cancer event during follow-up |
Cancer rate |
The proportion of women with breast cancer among the entire population receiving surveillance examinations |
In the entire population, the percentage of breast cancer both detected and undetected by surveillance |
Cancer detection rate |
The proportion of women with breast cancer detected by screening among the entire population receiving surveillance examinations |
In the entire population, percentage of breast cancer events detected by surveillance imaging |
Sensitivity |
The proportion of women with a second breast cancer event who have a positive surveillance examination |
Percentage of second breast cancer events during follow-up detected by the surveillance examination |
Specificity |
The proportion of women without a second breast cancer event who have a negative surveillance examination |
Percentage of examinations with no second breast cancer event during follow-up that were also negative on the surveillance examination |
Positive predictive value (PPV1) |
The probability that a woman has a second breast cancer event given that her surveillance examination is positive |
Likelihood of a true second breast cancer event in a woman who screens positive with a breast MRI |
Positive predictive value (PPV2) |
The probability that a women has a second breast cancer event among women recommended to receive a breast biopsy |
Likelihood of a true second breast cancer event in a women who screens positive with breast MRI and is recommended to receive a breast biopsy |
Positive predictive value (PPV3) |
The probability that a woman has a second breast cancer event among women who received a biopsy |
Likelihood of a true second breast cancer event in a woman who screens positive with breast MRI and receives a breast biopsy |