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Inhibitory Activities of Oxaprozin (5) and 22b against sEH Enzymes from Different Species
| human fl sEH |
mouse fl sEH |
rat fl sEH |
||||
|---|---|---|---|---|---|---|
| sEH-H | sEH-P | sEH-H | sEH-P | sEH-H | sEH-P | |
| 5 IC50(μM) | >300 | 70.0 ± 3.0 | >300 | 35.5 ± 5.8 | >300 | 62.5 ± 1.9 |
| 22b IC50 (μM) | 9.5 ± 0.5 | 4 ± 1 | >30 | >30 | >30 | 2.8 ± 2.2 |
