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Tertiary ether stereocenter formation.
 | |||||
|---|---|---|---|---|---|
| Entry[a] | Ligand R’ = | R= | T [°C] | Yield [%] | ee [%] |
| 1[b] | Bn (5 a) | Me | 0 | 29 | 34 |
| 2[b] | Ph (5 b) | Me | 0 | 86 | 15 |
| 3[b] | tBu (5d) | Me | 0 | 87 | −38 |
| 4 | tBu (5d) | Me | −78 to −28 | 87 | −67 |
| 5 | tBu (5d) | Et | −78 to −28 | 91 | −65 |
| 5 | tBu (5d) | iPr | −78 to −28 | 88 | −54 |
| 7 | tBu (5d) | tBu | −78 to −28 | 15 | −60 |
See the Supporting Information for detailed procedures.
Conducted in a two-step process in toluene, see procedure 1 in the Supporting Information for details.
