Table 3.

Amino acid analysis in each mouse at 15 weeks of age. Data expressed as means ± standard deviation.

Amino acid	Control	DKD	Tx
l‐Aspartic acid (nmol)	0.23 ± 0.04	0.16 ± 0.03 a	0.32 ± 0.24
l‐Arginine (nmol)	2.03 ± 0.16	1.83 ± 0.18	1.90 ± 0.23
l‐Ornithine (nmol)	1.24 ± 0.24	1.08 ± 0.11	0.95 ± 0.25
l‐Citrulline (nmol)	1.86 ± 0.14	2.24 ± 0.09 a	2.32 ± 0.14 c
l‐Arginine/l‐Citrulline ratio	1.17 ± 0.08	0.87 ± 0.07 b	0.84 ± 0.05 c

^a P‐value < 0.05: Control versus DKD at the same weeks of age

^b P‐value < 0.001: Control versus DKD at the same weeks of age

^c P‐value < 0.001: Control versus Tx mice at the same weeks of age.