Table 3.

Summary of the final results of all primary and secondary endpoints

Endpoints	Studies	Cases	OR/SMD	95%CI	P‐value	I2	P‐value	Favors
All‐cause RCs	24	7117	0.56	0.41, 0.78	<0.001	77%	<0.001	MIE
All‐cause AL	22	6925	1.08	0.92, 1.26	0.35	32%	0.08	None
All‐cause CCs	13	2302	0.97	0.74, 1.26	0.81	0%	0.99	None
In‐hospital stay	21	3265	−0.51	−0.78, −0.24	<0.001	96%	<0.001	MIE
Total operation time	23	2796	0.52	0.16, 0.89	0.005	95%	<0.001	OE
Blood loss	17	2160	−1.44	−1.95, −0.93	<0.001	96%	<0.001	MIE
R0 resection	13	2938	1.47	1.13, 1.92	0.004	0%	0.56	None
30‐day mortality	12	7976	0.92	0.69, 1.22	0.56	0%	0.95	None
90‐day mortality	6	1095	0.52	0.29, 0.91	0.02	0%	0.91	None
In‐hospital mortality	8	846	0.73	0.38, 1.41	0.35	0%	0.71	None
Reoperation	10	4767	1.30	0.85, 1.98	0.22	33%	0.14	None

AL, anastomotic leakage; CCs, cardiac complications; CI, confidence interval; MIE; minimally invasive esophagectomy; OE, open esophagectomy; OR; odds ratio; RCs, respiratory complications; SMD, standardized mean difference.