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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Cancer Immunol Res. 2017 Nov 9;6(1):59–68. doi: 10.1158/2326-6066.CIR-17-0026

Figure 2. Combination i.t. therapy with CD80-Fc plus CpG is more effective than CpG monotherapy.

Figure 2.

A, BALB/c mice were inoculated s.c. on day 0 with 1×105 CT26 colon carcinoma cells. On day 14 when the average tumor diameters were 6.4 – 6.7 mm, the mice were started on twice weekly i.t. injections of 20μg IgG, 200 μg CpG/mouse, or 200 μg CpG + 20μg CD80-Fc/mouse. I.t. injections were continued for three weeks. Graphs show average tumor volumes ± SD, percent surviving mice, and tumor growth in individual mice. Day 0 is the day of tumor inoculation. n= 5 mice/group. Statistical analysis was performed using pairwise comparison test.