TABLE 2.

Neural Regions Showing Main Effects and Interactions in Patients With Schizophrenia and Healthy Comparison Subjects in a Study of Direct- and Averted-Gaze Threat-Related Facial Expressions^a

		Coordinates
Effect and Region	Cluster Sizeb	x	y	z	Peak z
Main effect of group (comparison subjects > patients)
Left fusiform gyrus (Brodmann’s area 37)	396	−44	−58	−24	8.21
Right fusiform gyrus (Brodmann’s area 37)	309	42	−52	−24	8.08
Right thalamus	257	10	−6	6	7.3
Left cerebellum, declive	235	−24	−78	−22	8.21
Right cerebellum, declive	199	44	−80	−22	8.21
Right inferior frontal gyrus (Brodmann’s area 46)	92	46	30	8	7.89
Right lateral globus pallidus	70	30	−18	−2	6.54
Right lingual gyrus	89	20	−92	−4	6.77
Left lingual gyrus	88	−6	−92	−6	6.31
Main effect of group (patients > comparison subjects)
Right middle temporal gyrus (Brodmann’s area 37)	80	44	−66	−2	7.25
Gaze-by-group interaction (comparison subjects: averted > direct gaze, and patients: direct > averted gaze)
Right medial frontal gyrus (Brodmann’s area 10)	350	8	56	2	3.46
Left precentral gyrus (Brodmann’s area 44)	330	−58	18	4	4.12
Left lingual gyrus (Brodmann’s area 18)	183	−2	−84	2	3.57
Left putamen	110	−20	6	−6	3.41
Left inferior frontal gyrus (Brodmann’s area 10)	110	−50	42	−4	3.33
Emotion-by-gaze-by-group interaction
Left caudate	292	−12	4	4	3.59
Left caudate head		−10	10	0	3.27
Left thalamus		−10	−6	2	2.30
Left putamen		−22	8	−6	1.75
Right thalamus	238	14	−4	10	3.16
Right caudate body		12	8	6	3.08
Right caudate head		14	14	0	2.65

^aAnatomical labels and Brodmann’s areas, where appropriate, were assigned according to Talairach and Tournoux (40). Main effect clusters significant at p<0.05 (family-wise error corrected, cluster >50). Two-way interaction clusters significant at p<0.01, corrected. Three-way interaction clusters significant at p<0.05, corrected, and coordinates for a maximum of three local maxima at least 6 mm apart are reported for each cluster.

^bIn 2-mm³ voxels.