Table 2.

Relationship between composite active range of motion and measures of active function in the upper and lower limb studies (absolute values and changes from baseline).

Time point	Upper limb study				Lower limb study
	Week 4		Week 12		Week 4		Week 12
	Absolute values	Change from baseline	Absolute values	Change from baseline	Absolute values	Change from baseline	Absolute values	Change from baseline
Cycle 1 (n)	179	170	161	152	335	334	317	316
Correlation coefficient	0.575	0.052	0.621	0.122	0.221	−0.036	0.274	−0.021
P value	<0.0001	0.5007	<0.0001	0.1331	<0.0001	0.5158	<0.0001	0.7052
Cycle 2 (n)	158	148	137	128	286	285	252	252
Correlation coefficient	0.601	0.155	0.608	0.213	0.222	−0.052	0.211	−0.065
P value	<0.0001	0.0601	<0.0001	0.0160	0.0001	0.3854	0.0008	0.3059
Cycle 3 (n)	104	98	53	50	215	215	150	150
Correlation coefficient	0.636	0.296	0.476	0.059	0.186	−0.086	0.285	0.021
P value	<0.0001	0.0031	0.0003	0.6819	0.0064	0.2076	0.0004	0.8029
Cycle 4 (n)	46	43	0	0	134	134	0	0
Correlation coefficient	0.503	0.150	–	–	0.189	−0.025	–	–
P value	0.0004	0.3367	–	–	0.0284	0.7785	–	–

n: number of patients with data available.

Linear relationships analyzed using the Pearson correlation coefficient on absolute values and changes from baseline.