TABLE 2.
Association of Biomarkers With Disease Severity in Children With CAP, Adjusted for Age, Receipt of Antibiotics Before Arrival, Fever Duration, and Viral Pathogen Detected
| Biomarker | Suspected CAP, OR (95% CI) | Radiographic CAP, OR (95% CI) | ||||
|---|---|---|---|---|---|---|
| Mild Versus Mild-Moderate + Moderate-Severe + Severe | Mild + Mild-Moderate Versus Moderate-Severe + Severe | Mild + Mild-Moderate + Moderate-Severe Versus Severe | Mild Versus Mild-Moderate + Moderate-Severe + Severe | Mild + Mild-Moderate Versus Moderate-Severe + Severe | Mild + Mild-Moderate + Moderate-Severe Versus Severe | |
| WBC count | 1.06 (0.81–1.38) | 0.95 (0.75–1.2) | 1.3 (0.87–1.97) | 1.11 (0.75–1.63) | 1.05 (0.94–1.18) | 1.13 (0.69–1.96) |
| ANC | 1.06 (0.87–1.29) | 1.01 (0.85–1.2) | 1.31 (0.97–1.82) | 1.11 (0.82–1.48) | 1.11 (0.85–1.46) | 1.14 (0.77–1.76) |
| CRP | 1.19 (1.04–1.35) | 1.12 (1.00–1.25) | 1.22 (0.99–1.51) | 1.23 (1.01–1.51) | 1.08 (0.91–1.3) | 1.28 (0.93–1.82) |
| Procalcitonin | 1.11 (1.00–1.23) | 1.06 (0.98–1.16) | 1.13 (0.98–1.29) | 1.11 (0.97–1.28) | 1.05 (0.94–1.18) | 1.15 (0.96–1.37) |
Biomarkers were analyzed by using log2 transformation. OR is interpreted as the odds of developing the more severe outcome for every doubling of the biomarker value.