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High risk factors for distant metastases in HNSCC (from de Bree et al., 2018 7, mod.).
| Three or more cervical lymph node metastases |
| Extra-nodal spread |
| Low jugular lymph node metastases |
| Lymph node metastases greater than 6 cm |
| Bilateral cervical node metastases |
| Second primary head and neck tumour(s) |
| Regional recurrence |
| Primary tumour of the pharynx |
| T-stage (T3-T4) |
