Table 1.
Cell-cycle regulators that are caspase substrates
| Gene name | Protein name | Species | Cleavage sequence | References |
|---|---|---|---|---|
| ATP2B4 | PMCA4 | H | DEID (1080) | Pászty et al. 2002 |
| BUB1 | BUB1 | H | Undefined | Baek et al. 2005 |
| BUB1B | BUB1 beta/BUBR1 | H | DTCD (610), DVCD (579) | Kim et al. 2005 |
| CABLES2 | CDK5 and ABL1 enzyme substrate 2 | H | ISLDGRPP | Mahrus et al. 2008 |
| CCNA1 | Cyclin A1/A2 | X | DEPD (90) | Stack and Newport 1997 |
| CCNE1 | Cyclin E | H | LDVD (275) | Mazumder et al. 2002 |
| CCNT2 | Cyclin T2 | H | DVRDHYIA | Mahrus et al. 2008 |
| CDC27 | Cdc27 | H | Undefined | Zhou et al. 1998 |
| CDC42 | Cdc42 | H | DLRD (121) | Tu and Cerione 2001 |
| CDC5L | Cell division cycle 5–like protein | H | HESDFSGV | Mahrus et al. 2008 |
| CDC6 | Cdc6 | H | LVRD (99), SEVD (422) | Pelizon et al. 2002 |
| CDKN1A | Cyclin-dependent kinase inhibitor 1 | H | DHVD (112) | Gervais et al. 1998 |
| CDKN1B | p27Kip1 | H | DPSD (139), ESQD (108) | Levkau et al. 1998 |
| CENPF | Centromere protein F | H | Undefined | Dix et al. 2008 |
| CHAF1A | Chromatin assembly factor 1 sub A | H | EQPDSLVD | Mahrus et al. 2008 |
| CKAP5 | Cytoskeleton-associated protein 5 | H | IEND (1495) | Dix et al. 2008 |
| EIF4EBP1 | eIF4E-BP1 | H | VLGD (25) | Bushell et al. 2000 |
| EIF4G1 | eIF4G 1 | H | DLLD (492), DRLD (1136) | Marissen et al. 2000 |
| EIF4G2 | eIF4G 2 | H | DETD (790) | Marissen et al. 2000 |
| KIF11 | Kinesin-like protein KIF23 | H | Undefined | Dix et al. 2008 |
| MAX | Max | H | IEVE (10), SAFD (135) | Krippner-Heidenreich et al. 2001 |
| MCM2 | MCM2 | H | Undefined | Schwab et al. 1998 |
| MCM3 | MCM3 | H | Undefined | Schwab et al. 1998 |
| MCM4 | MCM4 | H | Undefined | Schwab et al. 1998 |
| MCM5 | DNA RLF MCM5 | H | FYSDSFGG | Mahrus et al. 2008 |
| MCM6 | DNA RLF MCM6 | H | SGVDGYET | Mahrus et al. 2008 |
| MDM2 | MDM2 | H | DVPD (359) | Erhardt et al. 1997 |
| MDM4 | MDMX | M | DVPD (361) | Gentiletti et al. 2002 |
| MKI67 | Antigen KI-67 | H | THTDKVPG | Mahrus et al. 2008 |
| PCM1 | Pericentriolar material 1 protein | H | EDGDGAGA | Mahrus et al. 2008 |
| POLA1 | DNA polymerase α catalytic subunit | H | Undefined | Dix et al. 2008 |
| POLE | DNA polymerase ε | H | DQLD (216), DMED (1214) | Liu and Linn 2000 |
| RB1 | Rb | H | DEAD (886) | Jänicke et al. 1996 |
| TMEM30A | Cell-cycle control protein 50A | H | DEVDGGPP | Mahrus et al. 2008 |
| TP53 | p53 | H | Undefined | Sayan et al. 2006 |
| WEE1 | Wee1 | H | Undefined | Zhou et al. 1998 |
(H) human, (X) Xenopus, (M) mouse.