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Figure 1.

Figure 1.

Schematic depicts the general process of generating differentiated brain cell types from adult humans. (Left to right) Biopsied somatic cells (such as dermal fibroblasts) from patients are reprogrammed to induced pluripotent stem cells (iPSCs) and differentiated to generate cells from different regions of the brain. Neuronal subtypes such as cortical, sensory, and motor neurons can be generated as well as glial cells such as oligodendrocytes, astrocytes, and microglia.