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. 2020 May 29;21(2):1470320320926049. doi: 10.1177/1470320320926049

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Changes of NLRP3, ASC and Caspase-1 levels in the myocardial tissues (mean±SD, n=6).

(a) NLRP3, (b) ASC and (c) Caspase-1 mRNA levels in myocardial tissues.

**p<0.01 vs. CON

^^p<0.01 vs. HC

^##p<0.01 vs. DM.

NLRP3: nucleotide binding oligomerization domain-like receptor protein 3; ASC: apoptosis-associated speck-like protein containing CARD; Caspase-1: cysteinyl aspartate specific proteinase-1; CON: control group; HC: high glucose and high fat group; DM: diabetes group; DM+Ir: diabetes +irbesartan group.