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. 2020 Jun 1;34(11-12):785–805. doi: 10.1101/gad.335836.119

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© 2020 Tsai et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — NDUFA5 mRNA colocalizes with mutant FUS aggregates. (A) U87 cells were transfected with GFP-tagged wild-type or R521C mutant FUS for 48 h. Immunofluorescence-FISH targeting GFP-FUS protein and NDUFA5 mRNA. Scale bar, 10 µm. (B) Colocalization analysis of NDUFA5 mRNA and R521C mutant FUS aggregates. Arrows indicate the aggregates for intensity profile analysis. (Green) GFP-FUS; (red) NDUFA5 FISH. Scale bar in insets, 2 µm (C) Colocalization analysis of IGFBP3 mRNA and R521C mutant FUS aggregates. Arrows indicate the aggregates for intensity profile analysis. (Green) GFP-FUS; (red) IGFBP3 FISH. Scale bar in insets, 2 µm.