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. 2020 May;30(5):790–801. doi: 10.1101/gr.250704.119

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© 2020 Fang et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — Associations of male reproduction and health traits with blood and immune tissues and cell types. (A) Reproduction traits have a significantly higher GWAS signal enrichment (−log₁₀P) than other types of traits in blood/immune tissues. We calculate P-values between groups using Student's t-test. (B) Enrichments of tissues and cell types with sire conception rate (SCR) and ketosis (KETO) disease. (C) Expression patterns of two fine-mapped genes across all 91 tissues and cell types, C6 (top; PPC = 1 for somatic cell score [SCS]) and CCDC88C (bottom; PPC = 1 for day of first birth [DFB]). (D) Associations of male reproduction and health traits with blood/immune tissues and cell types and four intestinal parts based on the GWAS signal enrichments of tissue-specific genes detected within these immune-relevant tissues and cell types. (*) Corrected-P (FDR) < 0.05.