Supplementary Table 2.
Association Between Abnormal Initial and Peak AST and ALT Levels and Outcomes
| Characteristic | N | Initial AST |
Peak AST |
|||||
|---|---|---|---|---|---|---|---|---|
| Abnormal, N = 491 | Normal, N = 376 | P valuea | N | Abnormal, N = 623 | Normal, N = 230 | P valuea | ||
| Intubation | 865 | 89 (18%) | 44 (12%) | .010 | 851 | 125 (20%) | 7 (3.0%) | <.001 |
| ICU admission | 864 | 88 (18%) | 41 (11%) | .005 | 850 | 123 (20%) | 5 (2.2%) | <.001 |
| Length of stay, d | 851 | 6 (3–11) | 5 (3–10) | .12 | 837 | 7 (4–12) | 4 (2–7) | <.001 |
| Mortality | 866 | 135 (28%) | 74 (20%) | .009 | 852 | 182 (29%) | 24 (10%) | <.001 |
| Initial ALT |
Peak ALT |
|||||||
|---|---|---|---|---|---|---|---|---|
| Abnormal, N = 347 | Normal, N = 520 | Abnormal, N = 503 | Normal, N = 348 | |||||
| Intubated | 865 | 57 (16%) | 75 (14%) | .4 | 849 | 103 (21%) | 27 (7.8%) | <.001 |
| ICU admission | 864 | 57 (17%) | 71 (14%) | .3 | 848 | 102 (20%) | 25 (7.2%) | <.001 |
| Length of stay, d | 851 | 6 (3–10) | 6 (3–10) | .5 | 835 | 7 (3–12) | 5 (3–9) | <.001 |
| Mortality | 866 | 71 (21%) | 138 (27%) | .052 | 850 | 129 (26%) | 76 (22%) | .2 |
NOTE. Data are presented as n (%).
ALT, alanine aminotransferase; AST, aspartate aminotransferase; ICU, intensive care unit.
a
Statistical tests performed included the Fisher exact test and the chi-square test of independence.