Figure 4.

CXCR3⁺ pDCs Traffic to A. fumigatus-Infected Lungs

(A) CXCR3 surface expression in BM (top row) and lung (bottom row) leukocytes isolated from WT (black lines) or Cxcr3^−/− mice (purple lines).

(B) Lung (blue filled dots) and BM (open black dots) pDC numbers at baseline and indicated times pi with 3 × 10⁷ CEA10 conidia (n = 5).

(C) Lung pDC numbers in WT (open black dots) and Cxcr3^−/− mice (open purple dots) at 72 h pi (n = 10).

(D) CCR2 surface expression in BM and lung pDCs in WT (black lines) or Ccr2^−/− mice (green lines).

(E) Lung pDC numbers in WT (open black dots) and Ccr2^−/− mice (open green dots) at 72 h pi (n = 10).

(B, C, and E) Data from 2–3 experiments were pooled and expressed as mean ± SEM. Statistical analysis: Mann-Whitney test. See also Figure S4.