Figure 5.

Sequential CCR2- and CXCR3-Dependent Signals Mediate Lung pDC Recruitment

(A) Experimental scheme to generate mixed BM chimeric mice and compare the trafficking of Cxcr3^−/−, Ccr2^−/−, and WT pDCs during A. fumigatus infection.

(B and C) Relative frequencies of (B) Cxcr3^−/− (open purple bars) and Cxcr3^+/+ (WT, open black bars) and (C) Ccr2^−/− (open green bars) and Ccr2^+/+ (WT, open black bars) pDCs in the BM, blood, and lung of mixed BM chimeric mice 72 h pi. Data from 2–3 experiments were pooled and expressed as mean ± SEM. Statistical analysis: Mann-Whitney test. See also Figure S5.