Table 1.
Interactome of BALF ligand to hDRG receptors.
| BALF Ligand | BALF Samples (CPM) |
Adjusted DEseq2 p-value | DRG receptor | DRG Samples (mean TPM) | ||
|---|---|---|---|---|---|---|
| Control 1 | Control 2 | COVID-19 | ||||
| ASIP | 0.544 | 0.482 | 19.505 | 2.84E-22 | MC1R | 4.766 |
| CCL2 | 4.143 | 9.142 | 356.403 | 5.06E-18 | CCR1 | 13.768 |
| CCL2 | 4.143 | 9.142 | 356.403 | 5.06E-18 | CCR2 | 2.936 |
| CCL3 | 9.082 | 5.934 | 79.201 | 2.22E-14 | CCR1 | 13.768 |
| CCL3 | 9.082 | 5.934 | 79.201 | 2.22E-14 | CCR4 | 0.402 |
| CCL3 | 9.082 | 5.934 | 79.201 | 2.22E-14 | CCR5 | 2.898 |
| CCL3L3 | 1.883 | 1.027 | 49.648 | 3.73E-17 | CCR5 | 2.898 |
| CCL4 | 16.051 | 9.247 | 73.881 | 3.12E-05 | CCR1 | 13.768 |
| CCL4 | 16.051 | 9.247 | 73.881 | 3.12E-05 | CCR5 | 2.898 |
| CCL7 | 0.042 | 0.252 | 14.776 | 2.74E-09 | CCR1 | 13.768 |
| CCL7 | 0.042 | 0.252 | 14.776 | 2.74E-09 | CCR2 | 2.936 |
| CCL8 | 0.628 | 0.650 | 34.281 | 8.02E-16 | CCR1 | 13.768 |
| CCL8 | 0.628 | 0.650 | 34.281 | 8.02E-16 | CCR2 | 2.936 |
| CCL8 | 0.628 | 0.650 | 34.281 | 8.02E-16 | CCR5 | 2.898 |
| CFH | 2.679 | 1.195 | 18.914 | 6.23E-05 | ITGAM | 19.044 |
| EFNA1 | 0.063 | 0.189 | 27.779 | 6.63E-08 | EPHA2 | 19.566 |
| EFNA1 | 0.063 | 0.189 | 27.779 | 6.63E-08 | EPHA3 | 25.688 |
| EFNA1 | 0.063 | 0.189 | 27.779 | 6.63E-08 | EPHB1 | 4.968 |
| EFNA5 | 0.000 | 0.000 | 6.502 | 2.43E-09 | EPHB1 | 4.968 |
| EFNA5 | 0.000 | 0.000 | 6.502 | 2.43E-09 | EPHB2 | 7.152 |
| EREG | 4.478 | 1.677 | 54.968 | 4.68E-08 | EGFR | 77.492 |
| F13A1 | 1.549 | 2.390 | 104.025 | 4.47E-04 | ITGA4 | 14.674 |
| F13A1 | 1.549 | 2.390 | 104.025 | 4.47E-04 | ITGA9 | 22.324 |
| F13A1 | 1.549 | 2.390 | 104.025 | 4.47E-04 | ITGB1 | 385.262 |
| FGF13 | 0.565 | 0.524 | 40.191 | 2.16E-23 | SCN5A | 7.426 |
| FGF13 | 0.565 | 0.524 | 40.191 | 2.16E-23 | SCN8A | 79.656 |
| IL15 | 19.189 | 16.691 | 85.702 | 1.35E-04 | IL15RA | 4.618 |
| NTN1 | 0.732 | 0.608 | 9.457 | 1.92E-06 | DCC | 1.926 |
| PTN | 0.000 | 0.021 | 9.457 | 1.36E-12 | PLXNB2 | 111.694 |
| TFF1 | 0.000 | 0.000 | 17.141 | 3.06E-13 | EGFR | 77.492 |
| TGFB2 | 0.105 | 0.189 | 8.866 | 4.35E-10 | TGFBR1 | 141.682 |
| TGFB2 | 0.105 | 0.189 | 8.866 | 4.35E-10 | TGFBR2 | 289.95 |
The average of gene abundances in the 2 COVID-19 samples, weighted by sequencing depth are shown here. Selected interactions are shown in the table. The full dataset is shown in Supplementary Table 3.