Table 2.
Interactome of hDRG ligand to BALF receptors.
| DRG Ligand | DRG Samples (mean TPM) | BALF Receptor | BALF Samples (CPM) |
Adjusted DEseq2 p-value | ||
|---|---|---|---|---|---|---|
| Control 1 | Control 2 | COVID-19 | ||||
| DCN | 1028.024 | EGFR | 0.167 | 0.356 | 33.690 | 3.61E-29 |
| EFNA1 | 14.852 | EPHB1 | 0.356 | 0.587 | 27.779 | 1.87E-25 |
| EFNA1 | 14.852 | EPHA5 | 1.214 | 1.447 | 14.185 | 8.30E-09 |
| EFNA1 | 14.852 | EPHA4 | 0.879 | 0.587 | 7.684 | 6.47E-05 |
| EFNA3 | 2.838 | EPHB1 | 0.356 | 0.587 | 27.779 | 1.87E-25 |
| EFNA3 | 2.838 | EPHA5 | 1.214 | 1.447 | 14.185 | 8.30E-09 |
| EFNA3 | 2.838 | EPHA4 | 0.879 | 0.587 | 7.684 | 6.47E-05 |
| EFNA4 | 5.342 | EPHA5 | 1.214 | 1.447 | 14.185 | 8.30E-09 |
| EFNA4 | 5.342 | EPHA4 | 0.879 | 0.587 | 7.684 | 6.47E-05 |
| EFNA5 | 19.364 | EPHB1 | 0.356 | 0.587 | 27.779 | 1.87E-25 |
| EFNA5 | 19.364 | EPHA5 | 1.214 | 1.447 | 14.185 | 8.30E-09 |
| EFNA5 | 19.364 | EPHA4 | 0.879 | 0.587 | 7.684 | 6.47E-05 |
| EFNB1 | 55.070 | EPHB1 | 0.356 | 0.587 | 27.779 | 1.87E-25 |
| EFNB1 | 55.070 | EPHA4 | 0.879 | 0.587 | 7.684 | 6.47E-05 |
| EFNB2 | 31.266 | EPHB1 | 0.356 | 0.587 | 27.779 | 1.87E-25 |
| EFNB2 | 31.266 | EPHA4 | 0.879 | 0.587 | 7.684 | 6.47E-05 |
| EFNB3 | 0.832 | EPHB1 | 0.356 | 0.587 | 27.779 | 1.87E-25 |
| EGF | 1.700 | ERBB4 | 0.188 | 0.776 | 66.789 | 2.38E-15 |
| EGF | 1.700 | EGFR | 0.167 | 0.356 | 33.690 | 3.61E-29 |
| EGF | 1.700 | ERBB3 | 0.314 | 0.776 | 7.684 | 1.91E-04 |
| EPGN | 0.786 | EGFR | 0.167 | 0.356 | 33.690 | 3.61E-29 |
| HBEGF | 16.790 | EGFR | 0.167 | 0.356 | 33.690 | 3.61E-29 |
| IGF1 | 30.036 | IGF1R | 6.131 | 7.758 | 38.418 | 5.53E-10 |
| LIF | 1.404 | LIFR | 0.105 | 0.356 | 15.367 | 6.10E-10 |
| NLGN1 | 20.258 | NRXN1 | 0.314 | 0.419 | 7.093 | 4.26E-07 |
| NLGN2 | 28.268 | NRXN1 | 0.314 | 0.419 | 7.093 | 4.26E-07 |
| NLGN3 | 66.420 | NRXN1 | 0.314 | 0.419 | 7.093 | 4.26E-07 |
| NLGN4X | 94.794 | NRXN1 | 0.314 | 0.419 | 7.093 | 4.26E-07 |
| NRG1 | 69.358 | ERBB4 | 0.188 | 0.776 | 66.789 | 2.38E-15 |
| NRG1 | 69.358 | ERBB3 | 0.314 | 0.776 | 7.684 | 1.91E-04 |
| NRG2 | 4.692 | ERBB4 | 0.188 | 0.776 | 66.789 | 2.38E-15 |
| NRG2 | 4.692 | ERBB3 | 0.314 | 0.776 | 7.684 | 1.91E-04 |
| NRG3 | 21.882 | ERBB4 | 0.188 | 0.776 | 66.789 | 2.38E-15 |
| NRG4 | 4.438 | ERBB4 | 0.188 | 0.776 | 66.789 | 2.38E-15 |
| NRG4 | 4.438 | EGFR | 0.167 | 0.356 | 33.690 | 3.61E-29 |
| NTN1 | 4.754 | DCC | 0.063 | 0.168 | 10.048 | 1.62E-11 |
| NTN4 | 28.880 | DCC | 0.063 | 0.168 | 10.048 | 1.62E-11 |
The average of gene abundances in the 2 COVID-19 samples, weighted by sequencing depth are shown here. Selected interactions are shown in the table. The full dataset is shown in Supplementary Table 5.