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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Semin Cell Dev Biol. 2019 Oct 9;100:11–19. doi: 10.1016/j.semcdb.2019.09.004

Fig. 2.

Fig. 2.

Representation of Yap regulation at the intercalated disc by Amot/Fat4. A) Amot/Fat4 binds and sequesters Yap, preventing nuclear localization and transcriptional activity. B) Genetic depletion of Amotl1 or Fat4 (indicated by red X) releases Yap membrane sequestration and therefore increases Yap nuclear translocation and transcriptional activity. Dashed lines indicate change in Yap localization following Amotl1 or Fat4 genetic depletion.