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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Semin Cell Dev Biol. 2019 Oct 9;100:11–19. doi: 10.1016/j.semcdb.2019.09.004

Fig. 3.

Fig. 3.

Representation of Yap regulation by the matrix interacting DGC and Agrin. A) phosphorylated Yap physically interacts with the DGC at the lateral surface of CMs thereby preventing Yap nuclear activity. The DGC is stabilized by lack of Agrin (indicated by red X). B) genetic depletion of DAG1 or Agrin overexpression both result in decreased sequestration of Yap to the lateral surface by the DGC, resulting in increased Yap nuclear activity. Dashed lines indicate change in Yap localization following destabilization of the DGC.