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Representation of Yap regulation by Cadherin/Catenin complexes at the intercalated disc. A) Yap is sequestered at the intercalated disc by physical interaction with the catenin/cadherin complex. B) Genetic depletion of α-catenins releases Yap from the cadherin/catenin complex thereby enhancing nuclear translocation of Yap. Dashed lines indicate change in Yap localization following depletion of α-catenins.
