TABLE 2.
Demographic and Biomarker Mean Values for the 2 Clusters Resulting From K-Cluster Analysisa
| Inflammation Cluster (n = 10) | High sGAG Cluster (n = 16) | P Valueb | |
|---|---|---|---|
| Age, y | 35.6 ± 7.9 | 33.1 ± 10.5 | .518 |
| Body mass index, kg/m2 | 23.4 ± 2.0 | 24.2 ± 3.6 | .533 |
| Days to surgery | 53.5 ± 14.5 | 70.4 ± 31.4 | .125 |
| Male:female, No. | 6:4 | 9:7 | >.99 |
| Allograft:autograft, No. | 3:7 | 6:10 | >.99 |
| Subjects without meniscus tears, No. | 7 | 6 | .226 |
| Biomarker, pg/mLc | |||
| IL-1ra | 258.78 ± 202.85 | 240.49 ± 140.12 | .774 |
| IL-1α | 0.30 ± 0.32 | 0.79 ±2.32 | .656 |
| IFN-γ | 12.75 ± 33.77 | 1.11 ± 0.80 | .075 |
| IL-10 | 1.39 ± 3.21 | 0.20 ± 0.10 | .005d |
| IL-6 | 235.45 ± 677.13 | 5.77 ± 5.02 | <.001d |
| IL-8 | 34.02 ± 21.07 | 16.06 ± 5.73 | .003d |
| TNF-α | 3.82 ± 7.27 | 1.04 ± 0.27 | <.001d |
| NTX, nM BCE | 10.03 ± 2.61 | 11.90 ± 4.30 | .235 |
| CTXII, ng/mL | 0.53 ± 0.27 | 0.71 ± 0.38 | .165 |
| COMP, μg/mL | 20.79 ± 4.30 | 25.13 ± 6.31 | .106 |
| sGAG, μg/mL | 26.10 ± 14.4 | 51.51 ± 28.79 | .003d |
| MMP-1 | 733,229.56 ± 325,378.1 | 303,345.81 ± 266,028.75 | .001d |
| MMP-3 | 5,355,011.97 ± 2,703,193.1 | 1,943,367.32 ± 1,417,831.36 | <.001d |
| MMP-9 | 10,049.67 ± 11,225.9 | 15,834.93 ± 41,490.24 | .309 |
| CPII, ng/mL | 748.43 ± 242.26 | 831.53 ± 303.09 | .543 |
| Bilirubin 1 biliverdin, μmol/L | 5.19 ± 3.71 | 3.69 ± 3.84 | .147 |
a
Values are presented as mean ± SD, unless noted otherwise. BCE, bone collagen equivalent; COMP, cartilage oligomeric matrix protein; CPII, procollagen II C-peptide; CTXII, C-terminal crosslinked telopeptide type II collagen; IFN-γ, interferon; IL, interleukin; MMP, matrix metalloproteinase; NTX, N-terminal telopeptide; sGAG, sulfated glycosaminoglycan; TNF-α, tumor necrosis factor a.
b
Difference between clusters.
c
Measured as pg/mL, unless noted otherwise.
d
P < .05.