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. Author manuscript; available in PMC: 2020 Jul 21.
Published in final edited form as: Sci Signal. 2020 Jan 21;13(615):eaay7315. doi: 10.1126/scisignal.aay7315

Figure 4. Synchronized redox regulation of cysteine residues throughout canonical EGF signaling pathways at 15 and 30 minutes.

Figure 4.

Select enriched canonical pathways from IPA downstream of EGFR are pictured. All genes with a significantly regulated cysteine residue are colored green. P < 0.05 based one-way ANOVA with Dunnett’s post-hoc test, N=3 independent biological replicates. Proteins detected but not significantly oxidized by EGF are filled in grey and those undetected, but important for continuity of a pathway, were left unfilled. EGF redox dynamics over 60 minutes for significantly changing peptides in each pathway are represented in heatmaps.