TABLE 1.
Statistical analysis for the comparison of the effects of BONP in the normalized amplitude and the normalized 1/latency of the Na+ current, where Mdn is the median.
|
Signed-rank test (Normalized Amplitude) | ||||||||||||||||||
|
ZN-BONP vs. BONP1 |
ZN-BONP vs. BONP2 |
ZN-BONP vs. BONP3 |
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| ZN-BONP Mdn | BONP1 Mdn | T | z | r | p | ZN-BONP Mdn | BONP2 Mdn | T | z | r | p | ZN-BONP Mdn | BONP3 Mdn | T | z | r | p | |
| Grand average | 100.00 | 105.85 | 30.00 | –3.57 | –0.71 | 0.0003 | 100.00 | 105.73 | 8.00 | –4.16 | –0.83 | 0.00003 | 100.00 | 110.65 | 1.00 | –4.35 | –0.87 | 0.00001 |
| Group 1 | 100.00 | 105.34 | 0.00 | –1.83 | –0.61 | 0.034 | 100.00 | 104.71 | 0.00 | –1.83 | –0.61 | 0.034 | 100.00 | 103.78 | 0.00 | –1.83 | –0.61 | 0.034 |
| Group 2 | 100.00 | 106.12 | 14.00 | –2.79 | –0.68 | 0.005 | 100.00 | 106.01 | 5.00 | –3.23 | –0.81 | 0.001 | 100.00 | 119.04 | 0.00 | –3.52 | –0.88 | 0.0004 |
| Group 3 | 100.00 | 101.66 | 4.00 | –0.94 | –0.42 | 0.17 | 100.00 | 103.45 | 1.00 | –1.75 | –0.78 | 0.04 | 100.00 | 106.52 | 1.00 | –1.75 | –0.78 | 0.04 |
|
ZN-BONP vs. BONP4 |
ZN-BONP vs. BONP5 |
BONP1 vs. BONP5, BONP3 vs. BONP5, or BONP4 vs. BONP5, |
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| ZN-BONP Mdn | BONP4 Mdn | T | z | r | p | ZN-BONP Mdn | BONP5 Mdn | T | z | r | p | BONP1, BONP3, or BONP4, Mdn | BONP5 Mdn | T | z | r | p | |
| Grand average | 100.00 | 106.73 | 13.00 | –4.02 | –0.8 | 0.0005 | 100.00 | 102.91 | 50.00 | –3.03 | –0.61 | 0.002 | 110.65 | 102.91 | 2.00 | –4.32 | 0.86 | 0.00001 |
| Group 1 | 100.00 | 102.95 | 0.00 | –1.83 | –0.61 | 0.034 | 100.00 | 102.90 | 0.00 | –1.83 | –0.61 | 0.034 | 105.34 | 102.90 | 0.00 | –1.83 | –0.61 | 0.034 |
| Group 2 | 100.00 | 106.63 | 7.00 | –3.52 | –0.88 | 0.002 | 100.00 | 102.91 | 22.00 | –2.38 | –0.59 | 0.017 | 119.04 | 102.91 | 0.00 | –3.52 | –0.88 | 0.0004 |
| Group 3 | 100.00 | 113.11 | 0.00 | –2.00 | –0.89 | 0.02 | 100.00 | 99.57 | 6.00 | –0.4 | –0.18 | 0.34 | 113.11 | 99.57 | 0.00 | –2.02 | –0.9 | 0.02 |
| Signed-rank test (Normalized 1/Latency) | ||||||||||||||||||
|
ZN-BONP vs. BONP1 |
ZN-BONP vs. BONP2 |
ZN-BONP vs. BONP3 |
||||||||||||||||
| ZN-BONP Mdn | BONP4 Mdn | T | z | r | p | ZN-BONP Mdn | BONP5 Mdn | T | z | r | p | BONP1, BONP3, or BONP4, Mdn | BONP5 Mdn | T | z | r | p | |
| Grand average | 100.00 | 102.18 | 29.00 | –3.59 | –0.72 | 0.0003 | 100.00 | 102.97 | 23.00 | –3.75 | –0.75 | 0.0001 | 100.00 | 104.86 | 5.00 | –4.23 | –0.85 | 0.00002 |
| Group 1 | 100.00 | 103.78 | 0.00 | –2.02 | –0.91 | 0.022 | 100.00 | 106.72 | 3.00 | –2.21 | –0.99 | 0.02 | 100.00 | 102.52 | 3.00 | –1.21 | –0.54 | 0.11 |
| Group 2 | 100.00 | 100.85 | 23.00 | –2.10 | –0.68 | 0.01 | 100.00 | 101.75 | 9.00 | –2.89 | –0.75 | 0.002 | 100.00 | 104.86 | 0.00 | –3.41 | –0.88 | 0.0006 |
| Group 3 | 100.00 | 103.14 | 0.00 | –2.02 | –0.91 | 0.022 | 100.00 | 104.64 | 0.00 | –2.02 | –0.91 | 0.022 | 100.00 | 106.39 | 0.00 | –2.02 | –0.91 | 0.022 |
|
ZN-BONP vs. BONP4 |
ZN-BONP vs. BONP5 |
BONP2 vs. BONP5, BONP3 vs. BONP5, or BONP4 vs. BONP5, |
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| ZN-BONP Mdn | BONP4 Mdn | T | z | r | p | ZN-BONP Mdn | BONP5 Mdn | T | z | r | p | BONP1, BONP3, or BONP4, Mdn | BONP5 Mdn | T | z | r | p | |
| Grand average | 100.00 | 104.44 | 19.00 | –3.86 | –0.77 | 0.0001 | 100.00 | 101.98 | 46.00 | –2.97 | –0.59 | 0.003 | 104.86 | 101.98 | 33.00 | –3.48 | 0.7 | 0.0004 |
| Group 1 | 100.00 | 101.24 | 4.00 | –0.94 | –0.42 | 0.17 | 100.00 | 103.73 | 1.00 | –1.46 | –0.65 | 0.07 | 106.72 | 103.73 | 1.00 | –2.02 | –0.91 | 0.04 |
| Group 2 | 100.00 | 102.94 | 5.00 | –3.12 | –0.81 | 0.001 | 100.00 | 101.24 | 30.00 | –1.71 | –0.44 | 0.044 | 104.86 | 101.24 | 0.00 | –3.41 | –0.88 | 0.0006 |
| Group 3 | 100.00 | 107.35 | 0.00 | –2.02 | –0.91 | 0.022 | 100.00 | 103.81 | 0.00 | –2.02 | –0.91 | 0.022 | 107.35 | 103.81 | 0.00 | –2.02 | –0.91 | 0.022 |
Because the data were not normally distributed (Kolmogorov-Smirnov normality test, P < 0.05) and had not homogeneity of variances (Levene test, P < 0.05), we performed several pairwise Signed-Rank Tests, under the null hypothesis that the differences between the aforementioned conditions were zero. The test of significance was one-tailed. Values of P < 0.05 were considered significant.