Table 2.
Alterations in Proteomic Profiles
| Proteins | Symbol | Strain A |
Strain B |
||||||
|---|---|---|---|---|---|---|---|---|---|
| 4 wk |
13 wk |
4 wk |
13 wk |
||||||
| 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | ||
| Viable | |||||||||
| Chitinase-like protein 3 | chil3 | 14.8* | — | — | 157.7* | — | — | 149.0* | 77.6* |
| Chitinase-like protein 4 | chil4 | 129.5* | — | 171.8* | 860.1* | — | — | 98.1* | — |
| Galectin-3 | lgals3 | 2.1* | — | 8.0* | 15.1* | — | −2.0* | — | 2.7* |
| Von Willebrand factor | vWF | — | — | 2.3* | — | — | −2.3 | — | — |
| Resistin-like α | retnla | NC* | — | — | NC* | — | — | 87.4* | NC* |
| Macrophage mannose receptor 1 | mrc1 | 3.5* | — | 3.7* | 7.5* | — | −2.1* | 2.1* | — |
| Eosinophil cationic protein 1 | ear1 | 30.5* | — | — | 162.9* | — | — | 9.3* | — |
| Eosinophil cationic protein 2 | ear2 | 25.6* | — | 29.4* | 111.1* | — | — | 8.5* | — |
| C-type lectins domain family | clec1a | — | — | — | — | — | — | −5.4* | — |
| Tetranectin | clec3b | — | — | 2.6* | — | — | −3.0* | — | — |
| Dectin-1 | clec7a | NC* | — | — | — | 14.6* | — | — | — |
| C-type lectin domain family | clec10a | NC* | — | 44.7* | 38.6* | — | — | 17.5* | — |
| C-type lectin domain family | clec14a | — | — | — | — | — | −6.7* | −3.3* | — |
| Surfactant protein A | sftpa | 2.1* | — | 3.1* | 6.0* | — | −2.2* | — | — |
| Surfactant protein D | sftpd | — | — | — | — | — | −3.0* | — | — |
| HIC | |||||||||
| Chitinase-like protein | chil3 | −2.2* | — | — | — | — | — | — | — |
| Chitinase-like protein | chil4 | — | — | — | — | — | — | — | — |
| Galectin-3 | lgals3 | −4.7* | −2.6* | — | — | — | −2.2* | — | — |
| Von Willebrand factor | vWF | −2.3* | −2.3* | — | — | — | −2.2* | — | — |
| Resistin-like α | retnla | — | — | — | — | — | — | — | — |
| Macrophage mannose receptor 1 | mrc1 | — | −2.8* | — | — | — | −3.5* | — | — |
| Eosinophil cationic protein 1 | ear1 | −7.3* | — | — | — | — | −15.8* | — | — |
| Eosinophil cationic protein 2 | ear2 | −8.0* | — | — | — | — | — | — | — |
| C-type lectins domain family | clec1a | −2.3* | — | — | — | — | — | −2.2* | — |
| Tetranectin | clec3b | — | −2.3* | — | — | — | −3.2* | — | — |
| Dectin-1 | clec7a | — | — | — | — | — | −4.8* | — | — |
| C-type lectin domain family | clec10a | — | — | — | — | — | — | — | — |
| C-type lectin domain family | clec14a | −2.7* | −3.7* | — | 2.2* | — | — | — | — |
| Surfactant protein A | sftpa | −6.4* | −2.2* | — | — | — | −2.4* | — | — |
| Surfactant protein D | sftpd | −14.0* | −5.6* | — | — | — | −5.0* | — | — |
Definition of abbreviations: HIC = heat-inactivated Stachybotrys chartarum conidia; NC = protein was detected in exposure group but not in air-only control group.
Values are reported as fold change between the exposed group and the air-only control group. Dashes indicate unchanged protein expression.
*
P ≤ 0.05; n = 3.