Table 3.

Strain A and Strain B 4-Week Exposure: Proteomic Core Analysis Summary Report Generated Using Ingenuity Pathway Analysis

4 wk	Strain A		Strain B
	24 h	48 h	24 h	48 h
Canonical pathways	Oxidative phosphorylation (2.8 × 10−22)	eIF2 signaling (4.4 × 10−04)	Mitochondrial dysfunction (1.1 × 10−02)	eIF2 signaling (1.3 × 10−25)
	Mitochondrial damage (9.1 × 10−22)	Antigen presentation pathway (1.6 × 10−03)	CDP-diacylglycerol biosynthesis I (7.6 × 10−03)	Integrin signaling (1.6 × 10−26)
Diseases and disorders	Organismal injury and abnormalities (1.3 × 10−02 to 1.2 × 10−15)	Organismal injury and abnormalities (3.6 × 10−02 to 5.1 × 10−06)	Inflammatory response (4.8 × 10−02 to 5.0 × 10−03)	Organismal injury and abnormalities (1.2 × 10−04 to 6.9 × 10−35)
	Inflammatory response (1.3 × 10−02 to 1.4 × 10−07)	Neurological disease (3.6 × 10−02 to 2.2 × 10−04)	Immunological disease (1.6 × 10−02 to 1.2 × 10−03)	Inflammatory response (8.9 × 10−05 to 2.1 × 10−11)
Physiological system development and function	Tissue morphology (1.3 × 10−02 to 5.3 × 10−07)	Hematological system development and function (3.6 × 10−02 to 3.2 × 10−04)	Organismal development (4.8 × 10−02 to 2.9 × 10−04)	Organismal survival (9.5 × 10−05 to 1.5 × 10−29)
	Hematological system development and function (1.3 × 10−02 to 1.4 × 10−07)	Lymphoid tissue structure and development (3.6 × 10−02 to 3.2 × 10−04)	Tissue development (3.3 × 10−03 to 2.9 × 10−04)	Cardiovascular system development and function (8.9 × 10−05 to 1.6 × 10−17)
	Immune cell trafficking (1.1 × 10−02 to 1.4 × 10−07)	Cell-mediated immune response (1.8 × 10−02 to 3.2 × 10−04)	Organ development (4.3 × 10−02 to 2.9 × 10−04)	Tissue development (1.1 × 10−04 to 1.7 × 10−18)
Cardiotoxicity	Cardiac enlargement (5.2 × 10−01 to 2.2 × 10−02)	Cardiac fibrosis (4.4 × 10−01 to 2.9 × 10−01)	Cardiac enlargement (2.8 × 10−01 to 5.5 × 10−03)	Cardiac enlargement (5.1 × 10−01 to 5.1 × 10−05)
	Cardiac dysfunction (1.0 × 1000 to 8.0 × 10−03)	Cardiac enlargement (1.1 × 1000 to 8.8 × 10−02)	Cardiac dysfunction (2.0 × 10−01 to 4.8 × 10−02)	Cardiac fibrosis (5.8 × 10−01 to 1.4 × 10−05)
	Cardiac proliferation (1.7 × 10−01 to 2.2 × 10−02)	Cardiac damage (5.8 × 10−02 to 5.4 × 10−02)	Cardiac inflammation (1.8 × 10−01 to 1.8 × 10−01)	Cardiac damage (9.1 × 10−02 to 7.6 × 10−05)

Definition of abbreviations: CDP = cytidine diphosphate; eIF2 = eukaryotic initiation factor 2.

P values associated with each pathway/disease are shown in parentheses.