Table 4.

Strain A and Strain B 13-Week Exposure: Proteomic Core Analysis Summary Report Generated Using Ingenuity Pathway Analysis

13 wk	Strain A		Strain B
	24 h	48 h	24 h	48 h
Canonical pathways	eIF2 signaling (1.4 × 10−30)	eIF2 signaling (2.2 × 10−42)	Gβγ signaling (9.3 × 10−08)	eIF2 signaling (4.5 × 10−25)
	Protein ubiquitination (1.0 × 10−19)	Mitochondrial dysfunction (1.1 × 10−29)	Integrin signaling (2.5 × 10−07)	Mitochondrial dysfunction (1.6 × 10−18)
Diseases and disorders	Organismal injury and abnormalities (7.3 × 10−03 to 4.0 × 10−31)	Organismal injury and abnormalities (1.2 × 10−03 to 3.6 × 10−39)	Organismal injury and abnormalities (7.6 × 10−03 to 1.6 × 10−06)	Organismal injury and abnormalities (5.4 × 10−03 to 5.4 × 10−28)
	Inflammatory response (7.3 × 10−03 to 1.3 × 10−09)	Inflammatory response (1.1 × 10−03 to 3.5 × 10−11)	Cardiovascular disease (7.5 × 10−03 to 1.6 × 10−06)	Inflammatory response (4.6 × 10−03 to 2.3 × 10−08)
Physiological system development and function	Hematological system development and function (7.3 × 10−03 to 5.5 × 10−06)	Hematological system development and function (1.3 × 10−03 to 2.1 × 10−09)	Organismal development (6.9 × 10−03 to 1.8 × 10−09)	Hematological system development and function (4.7 × 10−03 to 3.2 × 10−09)
	Tissue morphology (6.6 × 10−03 to 8.9 × 10−06)	Immune cell trafficking (1.3 × 10−03 to 2.2 × 10−09)	Cardiovascular system development and function (7.6 × 10−03 to 9.6 × 10−08)	Tissue morphology (5.3 × 10−03 to 9.3 × 10−09)
	Immune cell trafficking (7.3 × 10−03 to 5.6 × 10−06)	Tissue development (1.3 × 10−03 to 5.6 × 10−07)	Tissue morphology (7.6 × 10−03 to 1.3 × 10−06)	Lymphoid tissue structure and development (4.6 × 10−03 to 9.3 × 10−09)
Cardiotoxicity	Cardiac infarction (5.1 × 10−05 to 5.1 × 10−05)	Cardiac enlargement (4.6 × 10−01 to 7.9 × 10−04)	Cardiac fibrosis (4.5 × 10−01 to 1.1 × 10−03)	Cardiac enlargement (5.3 × 10−01 to 1.3 × 10−03)
	Cardiac dysfunction (4.7 × 10−01 to 9.5 × 10−03)	Cardiac fibrosis (5.4 × 10−01 to 2.8 × 10−03)	Cardiac inflammation (1.8 × 10−01 to 1.0 × 10−02)	Cardiac dysfunction (2.9 × 10−01 to 2.5 × 10−02)
	Cardiac inflammation (3.1 × 10−01 to 9.1 × 10−03)	Cardiac dysfunction (3.6 × 10−01 to 3.5 × 10−04)	Cardiac damage (1.4 × 10−01 to 1.8 × 10−03)	Heart failure (4.9 × 10−01 to 2.8 × 10−02)

P values associated with each pathway/disease are shown in parentheses.