Table 5.
Differentially Expressed Genes after Exposure
| Genes | Symbol | Strain A |
Strain B |
Strain A |
Strain B |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| 4 wk |
13 wk |
4 wk |
13 wk |
4 wk |
13 wk |
4 wk |
13 wk |
|||
| 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | |||
| Viable |
|
|||||||||
| Arginase-1 | arg1 | 13.4* | 12.5* | 3.8 | 9.8* | — |
— | 6.0* | 2.1 | |
| Cluster of differentiation 163 | cd163 | — | — | — | 8.9* | −2.6 |
— | — | — | |
| Cluster of differentiation 163 | cd163 | — | — | — | 67.3* | — |
— | — | — | |
| Chitinase-like 3 | chil3 | 20.9* | 15.0* | 81.8* | — | −2.3 |
2.8* | 32.1* | — | |
| C-type lectin domain family 4(n) | clec4n | 2.2* | — | 5.1* | — | −3.8* |
— | — | — | |
| Interleukin-33 | il33 | 3.9* | 2.8* | 5.2* | — | — |
— | 4.8* | — | |
| Mannose receptor | mrc1 | 5.8* | — | 4.2* | — | — |
— | 3.8* | −6.0 | |
| Resistin-like α | retnla | 247.6* | 60.6* | 145.1* | −3.9 | 9.0* |
39.0* | 108.2* | −3.5 | |
| Thymic stromal lymphopoietin | tslp | 3.3* | −2.6 | — | — | −3.4* |
−2.2* | 7.1* | — | |
| HIC |
|
|||||||||
| Arginase-1 | arg1 | 4.8* | — | — | 3.0 | — |
−4.3* | 2.6 | — | |
| C-C chemokine receptor 7 | ccr7 | — | — | — | 2.2 | — |
— | — | — | |
| Cluster of differentiation 163 | cd163 | 2.5* | — | 4.0* | 3.0 | — |
— | — | 2.3 | |
| Chitinase-like 3 | chil3 | — | — | — | −4.0* | — |
−2.1 | — | — | |
| C-type lectin domain family 4(n) | clec4n | — | — | — | — | — |
— | — | — | |
| Interleukin-33 | il33 | — | — | −2.8* | −3.8 | — |
— | — | — | |
| Mannose receptor | mrc1 | 2.1* | — | — | — | — |
— | — | −4.1 | |
| Resistin-like α | retnla | — | — | — | — | 2.3 |
— | — | −3.8* | |
| Thymic stromal lymphopoietin | tslp | 3.1* | — | — | — | 2.0 | — | — | — | |
Values are reported as fold change between the exposed group compared with air-only control group. Dashes indicate unchanged gene expression.
*
P ≤ 0.05; n = 3–5.