| 1 Incidence of gastric cancer ‐ modified ITT analysis substituting the 10‐year follow‐up data from Zhou 2008 with the 5‐year follow‐up data from Leung 2004 |
6 |
6532 |
Risk Ratio (M‐H, Random, 95% CI) |
0.69 [0.49, 0.98] |
| 2 Incidence of gastric cancer ‐ complete case analysis substituting the 10‐year follow‐up data from Zhou 2008 with the 5‐year follow‐up data from Leung 2004 |
6 |
5921 |
Risk Ratio (M‐H, Random, 95% CI) |
0.69 [0.48, 0.98] |
| 3 Incidence of gastric cancer‐ modified ITT analysis including the two arms of celecoxib from Wong 2012 |
6 |
7008 |
Risk Ratio (M‐H, Random, 95% CI) |
0.69 [0.48, 0.97] |
| 4 Incidence of gastric cancer ‐ modified ITT analysis including all randomised patients from Correa 2000 and You 2006 who were found subsequently to be ineligible or did not receive treatment |
6 |
6648 |
Risk Ratio (M‐H, Random, 95% CI) |
0.67 [0.47, 0.95] |
| 5 Incidence of gastric cancer ‐ missing data imputation based on various assumptions |
6 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 5.1 Assuming incidence of gastric cancer for missing participants in both arms same as observed in the trial control arm |
6 |
6497 |
Risk Ratio (M‐H, Random, 95% CI) |
0.66 [0.47, 0.94] |
| 5.2 Assuming incidence of gastric cancer for missing participants in treatment arm same as observed in the trial control arm, but no new gastric cancer cases in the control arm among those with missing data |
6 |
6497 |
Risk Ratio (M‐H, Random, 95% CI) |
0.69 [0.48, 0.98] |
