Comparison 1. D2 versus D1.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall survival	5	1653	Hazard Ratio (Random, 95% CI)	0.91 [0.71, 1.17]
2 Disease specific survival	4	1599	Hazard Ratio (Fixed, 95% CI)	0.81 [0.71, 0.92]
3 Disease free survival	3	1332	Hazard Ratio (Fixed, 95% CI)	0.95 [0.84, 1.07]
4 Postoperative mortality	5	1653	Risk Ratio (IV, Fixed, 95% CI)	2.02 [1.34, 3.04]