Date	Event	Description
14 February 2008	New search has been performed	Twenty‐one new studies were added in the 2007 update (published in Issue 2, 2008 of The Cochrane Library).
13 February 2008	New citation required and conclusions have changed	There are now 78 studies meeting our criteria for testing interventions to help patients to follow prescribed, self administered medications. Despite the new studies, our conclusions remain the same: most people do not follow self administered medical treatments as prescribed and interventions to help them follow treatments are marginally effective at best, especially for long‐term medical regimens. Strategies that appear to have some effect for long‐term regimens involve combinations of counseling, reminders, self monitoring, feedback, family therapy, psychological therapy, manual telephone follow‐up, and supportive care. For short‐term treatments, high adherence can be achieved by simpler means, including counseling, written information about the importance of taking all doses, and personal phone calls. The authorship changed to: Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X.
29 August 2005	New citation required and conclusions have changed	The title changed to 'Interventions for enhancing medication adherence.' The authorship changed to: Haynes RB, Yao X, Degani A, Kripalani S, Garg A, McDonald HP.
29 August 2005	New search has been performed	Twenty‐five new studies were added (Issue 4, 2005), bringing to 57 the number of randomized trials meeting our criteria for testing interventions for helping patients to follow prescribed, self administered medications. Despite the new studies, conclusions remained essentially the same: most people do not follow self administered medical treatments as prescribed and interventions to help them follow treatments are marginally effective at best, especially for long‐term medical regimens. Strategies that appear to have some effect for long‐term regimens involve combinations of counseling, reminders, self monitoring, feedback, family therapy, psychological therapy, manual telephone follow‐up, and supportive care. For short‐term treatments, high adherence can be achieved by simpler means, including counseling, written information about the importance of taking all doses, and personal phone calls.
7 February 2002	New search has been performed	Fourteen new studies were added (Issue 2, 2002), bringing to 33 the number of randomized trials meeting our criteria for testing interventions for helping patients to follow prescribed, self administered medications. Despite the new studies, conclusions remain the same: most people do not follow self administered medical treatments as prescribed and interventions to help them follow treatments are marginally effective at best, especially for long‐term medical regimens. Strategies that appear to have some effect for long‐term regimens involve combinations of counseling, reminders, self monitoring and feedback, and supportive care. For short‐term treatments, high adherence can be achieved by simpler means, including reminders and instruction about the importance of taking all doses.
7 February 2002	New citation required but conclusions have not changed	The updated citation reflects the updated search and new authorship: Haynes RB, McDonald H, Garg AX, Montague P.