TABLE 2.
Most Significant SNPs Associated with Foot Dorsiflexion in European Cohort
| SNP | Chr | BP (hg19) | Effect Allele | Ref Allele | Gene | Beta | SE | p | OR | 95% CI for OR |
|---|---|---|---|---|---|---|---|---|---|---|
| rs10910527 | 1 | 232,599,189 | T | C | SIPA1L2 | 2.549 | 0.471 | 6.30E-08 | 12.794 | 5.083–32.206 |
| rs7536385 | 1 | 232,601,208 | G | A | SIPA1L2 | 2.549 | 0.471 | 6.30E-08 | 12.794 | 5.083–32.206 |
| rs4649265 | 1 | 232,591,925 | C | A | SIPA1L2 | 2.387 | 0.449 | 1.06E-07 | 10.881 | 4.513–26.234 |
| rs1547740 | 1 | 232,576,594 | T | G | SIPA1L2 | 2.385 | 0.450 | 1.13E-07 | 10.859 | 4.495–26.233 |
| rs303143 | 4 | 124,155,197 | G | A | SPATA5 | −3.407 | 0.689 | 7.60E-07 | 0.033 | 0.009–0.128 |
| rs2213767 | 22 | 27,370,782 | T | C | 1.396 | 0.304 | 4.37E-06 | 4.039 | 2.226–7.329 | |
| rs641712 | 1 | 86,488,232 | A | G | COL24A1 | −0.881 | 0.198 | 8.51E-06 | 0.414 | 0.281–0.611 |
| rs11007056 | 10 | 28,652,892 | A | G | −1.036 | 0.234 | 9.88E-06 | 0.355 | 0.224–0.561 | |
| rs16859600 | 1 | 233,928,834 | A | G | 1.285 | 0.294 | 1.24E-05 | 3.615 | 2.031–6.432 | |
| rs10158853 | 1 | 177,940,612 | G | A | −1.036 | 0.239 | 1.46E-05 | 0.355 | 0.222–0.567 | |
| rs2366812 | 2 | 85,954,544 | G | T | −0.917 | 0.212 | 1.46E-05 | 0.400 | 0.264–0.606 | |
| rs5924090 | 23 | 86,954,001 | A | C | 1.025 | 0.241 | 2.14E-05 | 2.787 | 1.738–4.470 | |
| rs10913485 | 1 | 177,965,223 | C | T | −1.016 | 0.240 | 2.22E-05 | 0.362 | 0.226–0.579 | |
| rs17066814 | 5 | 165,825,034 | G | A | 1.640 | 0.387 | 2.24E-05 | 5.155 | 2.414–11.007 | |
| rs17025973 | 4 | 150,168,192 | C | T | 1.934 | 0.457 | 2.34E-05 | 6.917 | 2.824–16.941 | |
| rs17026072 | 4 | 150,202,270 | G | A | 1.934 | 0.457 | 2.34E-05 | 6.917 | 2.824–16.941 | |
| rs7743652 | 6 | 25,502,076 | A | G | LRRC16A | 0.764 | 0.181 | 2.45E-05 | 2.147 | 1.506–3.061 |
| rs482014 | 6 | 125,365,295 | T | C | RNF217 | 0.915 | 0.217 | 2.52E-05 | 2.497 | 1.632–3.82 |
| rs9375383 | 6 | 125,354,154 | C | A | RNF217 | 0.939 | 0.223 | 2.64E-05 | 2.557 | 1.652–3.959 |
| rs3094204 | 6 | 31,091,992 | T | C | PSORS1C1 | 0.726 | 0.175 | 3.32E-05 | 2.067 | 1.467–2.912 |
| rs1705984 | 3 | 194,266,725 | A | C | −1.035 | 0.251 | 3.61E-05 | 0.355 | 0.217–0.581 | |
| rs1536510 | 9 | 126,935,882 | T | C | 1.079 | 0.262 | 3.75E-05 | 2.942 | 1.76–4.916 | |
| rs5909373 | 23 | 17,566,980 | A | C | NHS | −0.795 | 0.194 | 4.02E-05 | 0.452 | 0.309–0.66 |
| rs16955656 | 16 | 81,644,493 | T | G | CMIP | 1.498 | 0.368 | 4.68E-05 | 4.473 | 2.174–9.201 |
| rs1341296 | 11 | 29,363,716 | C | T | −0.822 | 0.202 | 4.70E-05 | 0.440 | 0.296–0.653 | |
| rs6759087 | 2 | 85,948,793 | A | G | −1.016 | 0.250 | 4.74E-05 | 0.362 | 0.222–0.591 |
BP = base pair; CI = confidence interval; OR = odds ratio; SE = standard error; SNP = single nucleotide polymorphism.