Comparison 1. Treatment Regimens.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 6‐month survival	30	5755	Risk Ratio (M‐H, Random, 95% CI)	1.04 [1.00, 1.09]
1.1 Undifferentiated	10	1808	Risk Ratio (M‐H, Random, 95% CI)	1.02 [0.94, 1.10]
1.2 Limited Disease	8	1044	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.94, 1.07]
1.3 Extensive Disease	18	2903	Risk Ratio (M‐H, Random, 95% CI)	1.09 [1.02, 1.17]
2 12‐month survival	31	6034	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.97, 1.16]
2.1 Undifferentiated	10	1808	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.82, 1.22]
2.2 Limited Disease	9	1209	Risk Ratio (M‐H, Random, 95% CI)	1.15 [0.95, 1.39]
2.3 Extensive Disease	19	3017	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.94, 1.18]
3 24‐month survival	27	5398	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.85, 1.31]
3.1 Undifferentiated	10	1808	Risk Ratio (M‐H, Random, 95% CI)	0.97 [0.71, 1.33]
3.2 Limited Disease	9	1209	Risk Ratio (M‐H, Random, 95% CI)	1.07 [0.70, 1.65]
3.3 Extensive Disease	15	2381	Risk Ratio (M‐H, Random, 95% CI)	1.11 [0.71, 1.75]
4 Overall response	31	5651	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.98, 1.13]
4.1 Undifferentiated	11	2225	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.89, 1.21]
4.2 Limited Disease	8	809	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.94, 1.12]
4.3 Extensive Disease	18	2617	Risk Ratio (M‐H, Random, 95% CI)	1.07 [0.96, 1.19]
5 Complete response	30	5599	Risk Ratio (M‐H, Random, 95% CI)	1.32 [1.14, 1.54]
5.1 Undifferentiated	10	2175	Risk Ratio (M‐H, Random, 95% CI)	1.26 [0.90, 1.77]
5.2 Limited Disease	8	809	Risk Ratio (M‐H, Random, 95% CI)	1.19 [1.02, 1.40]
5.3 Extensive Disease	18	2615	Risk Ratio (M‐H, Random, 95% CI)	1.45 [1.17, 1.80]
6 Toxic Death	20	3696	Risk Ratio (M‐H, Random, 95% CI)	1.08 [0.72, 1.62]
7 Nausea and Vomiting	22	3961	Risk Ratio (M‐H, Random, 95% CI)	1.52 [1.22, 1.88]
8 Alopecia	8	1526	Risk Ratio (M‐H, Random, 95% CI)	1.14 [1.00, 1.30]
9 Infection	12	2184	Risk Ratio (M‐H, Random, 95% CI)	0.69 [0.43, 1.09]
10 Anaemia	12	2219	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.86, 1.67]
11 Leukopenia	17	2556	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.67, 1.05]
12 Thrombocytopenia	19	3276	Risk Ratio (M‐H, Random, 95% CI)	1.89 [1.37, 2.61]
12.1 New Subgroup	19	3276	Risk Ratio (M‐H, Random, 95% CI)	1.89 [1.37, 2.61]
13 Granulocytopenia	5	1229	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.79, 1.00]