Figure 4. Effects of miR-145 on the cell viability and inflammation in the macrophages upon Mtb infection. A and B. Expression of miR-145 was successfully regulated in both THP-1 and RAW264.7 cells. C and D. The overexpression of miR-145 could suppress, whereas the downregulation of miR-145 could promote the cell viability of the macrophages. E and F. The concentrations of IL-1β and TNF-α in the macrophages upon Mtb infection were inhibited by the upregulation of miR-145, but were enhanced by the knockdown of miR-145. *P < 0.05, **P < 0.01, ***P < 0.001 vs. Infection control.