Figure 5. CXCL16 is a direct target gene of miR-145. A. A complete sequence of miR-145 was found in the 3’-UTR of CXCL16. B. Luciferase activity in WT group was suppressed by the overexpression of miR-145, but was promoted by the knockdown of miR-145 in both THP-1 and RAW264.7 cell lines. WT, wild type; MT, mutant type; **P < 0.01 vs. Untreated.