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. 2020 May 20;128(5):057001. doi: 10.1289/EHP6301

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EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

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Figures 8A to 8F have boxplots under the column labeled Nonmonotonic response plotting sd width 3D, ranging from 10 to 18 in increments of 4; Thickness in micrometers, ranging from 60 to 140 in increments of 40, dimension 3D, ranging from 1.8 to 2.2; Angle between beginning and end, ranging from 26 to 35 in increments of 4; Dim 3, ranging from 0 to 10 in increments of 10; and AR, ranging from 1.5 to 3.5 in unit increments, respectively, (y-axis) across Control, 2.5BPA, 25BPA, 250BPA, 2500BPA, and 25000BPA (x-axis). The schematics of their corresponding morphological features are illustrated under the columns labeled low-value illustration and high-value illustration. — Nonmonotonic responses to BPA doses [x-axis, BPA $mg / kg$ body weight (BW) per day] shown by nonlinear regression in PND21C animals and illustration of the corresponding morphological features. Number of animals per group $n = 8 - 10$ . Units: $μ g / kg$ BW per day. The midline represents the median, the box represents the quartiles above and below the median, and the whiskers represent the two other quartiles, excluding outliers. (A–F) Graphs representing mean and standard deviation for each dose and the fit with the combination of a linear and step function. Left photomicrograph panels are representative images of a low value, right panels illustrate high values. $Scale bars = 2 mm$ . All features but the aspect ratio (F) show a break between 25BPA and 250BPA. In (F) the break is between 250BPA and 2500BPA. (A) Mean variation of ductal thickness: the gland on the right has many structures that have both thin and thick parts, whereas the gland on the left has more regular structures. (B) Mean thickness of the epithelium: the brightness in the pictures is proportional to the local thickness of the points of the gland. (C) Fractal dimension in 3D. The gland on the right grows more conspicuously in the third dimension than in the left figure. (D) Angle between the beginning and the end of ducts: ducts are straighter on the left and turn more on the right. (E) Third dimension from PCA. (F) AR: A large AR leads to an elongated gland, whereas a low AR means that the gland is round. Low doses of BPA increase the roundness of glands and high doses lead to an AR similar to control. Note: AR, aspect ratio; BPA, bisphenol A; Control, vehicle control; PCA, principal component analysis; PND, postnatal day; 3D, three-dimensional.