Table 2.

Number of features for which the largest change takes place between consecutive conditions in the chronic study.

Data set	$\text{Control}–2.5\text{BPA}$	$2.5–25\text{BPA}$	$25–250\text{BPA}$	$250–2500\text{BPA}$	$2500–25000\text{BPA}$	X(t)	$X_{\text{observed}}$	p-Value
PND21C (training set)	14	5	57	6	9	0.62	0.62	0.0094
PND90CD continuous	2	7	6	6	1	0.27	1.37	0.0038
PND90SD	3.5	3.5	7	1	3	0.39
6MCD	5	3	9.5	0	6.5	0.40
6MSD	3.5	8	7.5	2	3	0.31

Note: For Criterion B with $p_{\text{thr}}=0.5$, we find $X_{\text{observed}}=0.27+0.39+0.40+0.31=1.37$. (Table 3 reports the significance of these results.) Non-integer values stem from ties. Total number of features were 94 (PND21), 24 (PND90), and 26 (6M). BPA, bisphenol A; CD, continuous dose; M, month; PND, postnatal day; SD, stop-dose.