Table 3.

Comparison of $X_{\text{observed}}$ and the results of the permutation test between 25 and 250BPA in PND90CD, PND90SD, 6MCD and 6MSD data sets analyzed together.

Criterion	$X_{\text{observed}}$	95% of $X_{\text{sim}}<$	99.5% of $X_{\text{sim}}<$	$p_{\text{estimated}}$	$p_{\text{estimated}}$ (litter)
A(1.2)	1.67	1.13	1.38	0.00016	0.00016
B(0.5)	1.37	1.12	1.35	0.0038	0.0042

Note: Results for other thresholds can be found in Table S3. Criterion A(1.2) [B(0.5)] means that the ratio (p-value of a t-test, respectively) between successive means has to be at least 1.2 [0.5] to be taken into account. BPA, bisphenol A; CD, continuous dose; M, month; PND, postnatal day; SD, stop-dose.